TAK-242
Catalogue number:
CAY13871-25 mg
Supplier:
Size:
25 mg
Product is available in:
£1045.00
Estimated delivery Wed 7 Aug
Shipping is calculated in checkout
Shipping is calculated in checkout
This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
243984-11-4
Purity:
≥98%
Formulation:
A crystalline solid
Molecular Weight:
361.8
Alternative Names:
6r-[[(2-chloro-4-fluorophenyl)amino]sulfonyl]-1-cyclohexene-1-carboxylic acid, ethyl ester, resatorvid
- Data sheet: View or download
- MSDS: View or download
Product Description:
A TLR4 antagonist (IC50 = 0.68 µM in a SEAP assay); selectively binds to TLR4 over TLR1-3 and TLR5-10 at 100 nM; prevents the interaction of TLR4 with TIRAP or TRAM in HEK293 cells expressing the human receptors at 1 µM; inhibits IFN-γ- and LPS-induced production of NO, TNF-α, IL-6, and IL-1β in isolated mouse peritoneal macrophages (IC50s = 5.7-11 nM); inhibits LPS-induced NETosis in isolated human neutrophils at 5-20 µM; improves survival in a mouse model of LPS-induced septic shock at 0.3, 1, and 3 mg/kg
Storage Temperature:
-20°C
