KD 025
Catalogue number:
CAY17055-10 mg
Supplier:
Size:
10 mg
Product is available in:
£77.00
Estimated delivery Wed 7 Aug
Shipping is calculated in checkout
Shipping is calculated in checkout
This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
911417-87-3
Purity:
≥98%
Formulation:
A crystalline solid
Molecular Weight:
452.5
Alternative Names:
2-[3-[4-(1h-indazol-5-ylamino)-2-quinazolinyl]phenoxy]-n-(1-methylethyl)-acetamide, belumosudil, slx-2119
- Data sheet: View or download
- MSDS: View or download
Product Description:
A ROCK2 inhibitor (IC50 = 0.105 µM); selective for ROCK2 over ROCK1 (IC50 = 24 µM); decreases the expression of CTGF and induces remodeling of the actin cytoskeleton in isolated human ileal fibrotic smooth muscle cells at 10 µM; inhibits heat-killed C. albicans- or S. epidermidis-induced production of IL-17 in isolated human PBMCs at 1.25-10 µM; reduces infarct volume in a mouse model of cerebral ischemia induced by transient MCAO at 100 and 200 mg/kg; decreases disease severity in a mouse model of sclerodermatous chronic GVHD at 150 mg/kg
Storage Temperature:
-20°C
