4’-hydroxy Tamoxifen
Catalogue number:
CAY19519-1 mg
Supplier:
Size:
1 mg
Product is available in:
£216.00
Estimated delivery Wed 7 Aug
Shipping is calculated in checkout
Shipping is calculated in checkout
This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
82413-23-8
Purity:
≥98% (may contain up to 10% of the (E) isomer)
Formulation:
A crystalline solid
Molecular Weight:
387.5
Alternative Names:
4-[(1z)-1-[[4-[2-(dimethylamino)ethoxy]phenyl]phenylmethylene]propyl]-phenol
- Data sheet: View or download
- MSDS: View or download
Product Description:
An ER antagonist and active metabolite of tamoxifen (IC50 = 2.4 nM for the rabbit receptor); inhibits the proliferation of MCF-7 and MDA-MB-231 cells (IC50s = 27 and 16 µM, respectively); reduces the survival percentage of HEC-1B and HEC-1A cells at 10 and 100 nM; administration of liposomes encapsulating 4'-hydroxy tamoxifen (4 mg/kg twice per week) reduces tumor growth in an RPMI-8226 multiple myeloma mouse xenograft model
Storage Temperature:
-20°C