Quininib
Catalogue number:
CAY19838-1 mg
Supplier:
Size:
1 mg
Product is available in:
£80.00
Estimated delivery Wed 7 Aug
Shipping is calculated in checkout
Shipping is calculated in checkout
This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
143816-42-6
Purity:
≥98%
Formulation:
A crystalline solid
Molecular Weight:
247.3
Alternative Names:
2-[(1e)-2-(2-quinolinyl)ethenyl]-phenol
- Data sheet: View or download
- MSDS: View or download
Product Description:
A CysLT1 and CysLT2 receptor antagonist (IC50s = 1.4 and 52 µM, respectively); inhibits tubule formation in HMEC-1 cells at 3.16 and 10 µM; inhibits sprout formation in isolated mouse aortic rings at 10 µM; decreases angiogenesis in an oxygen-induced retinopathy mouse model of ocular angiogenesis, preventing revascularization at 0.5 and 3 µM, as well as increasing neovascularization and vascular density at 3 µM; reduces tumor growth and inhibits angiogenesis in an HT-29 colorectal cancer mouse xenograft model at 50 mg/kg every three days
Storage Temperature:
-20°C
