Trigonelline (chloride)
Shipping is calculated in checkout
6138-41-6
≥95%
A crystalline solid
173.6
3-carboxy-1-methyl-pyridinium, monochloride, n-methyl nicotinic acid betaine
- Data sheet: View or download
- MSDS: View or download
An alkaloid with diverse biological activities; increases levels of the brown fat marker proteins PRDM16, PGC-1α, and UCP1 in 3T3-L1 adipocytes at 75 µM; inhibits degranulation of, and decreases the production of IL-6 and TNF-α in, activated primary mouse BMMCs; reduces serum IgE levels, pulmonary immune cell infiltration, and mucus secretion in a mouse model of ovalbumin-induced allergic asthma at 200 mg/kg; reduces serum levels of IL-1β, IL-6, IL-18, and MDA and renal cell apoptosis, as well as increases protein levels of PPARγ in a rat model of high-fat diet- and streptozotocin-induced type 2 diabetic nephropathy at 40 mg/kg; reduces hepatic de novo lipogenesis, induces hepatic autophagy, and prevents weight gain, insulin resistance, and hepatic steatosis in a mouse model of high-cholesterol and high-fat diet-induced NAFLD at 50 mg/kg
-20°C
