NSC 109555
Shipping is calculated in checkout
15427-93-7
≥98%
A crystalline solid
600.7
2,2'-[carbonylbis(imino-4,1-phenyleneethylidyne)]bis-hydrazinecarboximidamide, dimethanesulfonate, ddug, nci c04808
- Data sheet: View or download
- MSDS: View or download
An inhibitor of Chk2 (IC50 = 200 nM in a cell-free kinase assay); selective for Chk2 over Chk1 and 16 kinases in a panel but does inhibit Brk, c-Met, IGFR, and LCK (IC50s = 210, 6,000, 7,400, and 7,100 nM, respectively); inhibits Chk2 autophosphorylation and phosphorylation of the Chk2 substrate histone H1 in vitro (IC50 = 240 nM); inhibits the growth of, and induces autophagy in, L1210 leukemia cells in vitro; potentiates gemcitabine-induced cytotoxicity in MIA PaCa-2, CFPAC-1, PANC-1, and BxPC-3 pancreatic cancer cells, as well as reduces gemcitabine-induced increases in Chk2 phosphorylation and enhances gemcitabine-induced production of ROS in MIA PaCa-2 cells at 1,250 nM
-20°C
