Ceritinib
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1032900-25-6
≥98%
A crystalline solid
558.1
5-chloro-n4-[2-[(1-methylethyl)sulfonyl]phenyl]-n2-[5-methyl-2-(1-methylethoxy)-4-(4-piperidinyl)phenyl]-2,4-pyrimidinediamine, ldk 378
- Data sheet: View or download
- MSDS: View or download
An ALK inhibitor (IC50 = 0.2 nM); selective for ALK over IGF-1R, InsR, STK22D, and FLT3 (IC50s = 8, 7, 23, and 60 nM, respectively) as well as a panel of 25 additional kinases (IC50s = >0.26 µM for all); inhibits the proliferation of Ba/F3 cells expressing the fusion protein NPM-ALK or ELM4-ALK (IC50s = 0.02 and 0.021 µM, respectively), as well as several crizotinib-resistant NPM-ALK and ELM4-ALK mutants; reduces tumor growth in an H2228 NSCLC rat xenograft model at 10 mg/kg per day and induces tumor regression at 25 mg/kg per day; induces tumor regression in a Karpas299 lymphoma rat xenograft model at 25 and 50 mg/kg per day
-20°C
