Aztreonam
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78110-38-0
≥95%
A crystalline solid
435.4
2-[[(z)-[1-(2-amino-4-thiazolyl)-2-[[(2s,3s)-2-methyl-4-oxo-1-sulfo-3-azetidinyl]amino]-2-oxoethylidene]amino]oxy]-2-methyl-propanoic acid, sq 26,776
- Data sheet: View or download
- MSDS: View or download
A synthetic β-lactam antibiotic of the monobactam class; active against clinical isolates of E. coli, S. marcescens, P. aeruginosa, Klebsiella species, Proteus species, and Enterobacter species (MICs = S. pneumoniae, B. fragilis, and S. faecalis (MICs = >100 µg/ml for all); interferes with peptidoglycan synthesis in the bacterial cell wall of the Gram-negative bacteria E. coli, P. vulgaris, E. cloacae, K. pneumoniae, and P. aeruginosa by inhibiting penicillin-binding protein 3 (PBP3; IC100 = 0.1 µg/ml for all); increases survival in mice with systemic Gram-negative bacterial infections (ED50s = 0.1-24.7 mg/kg)
-20°C
