IT-901
Catalogue number:
CAY22298-1 mg
Supplier:
Size:
1 mg
Product is available in:
£41.00
Estimated delivery Wed 24 Dec
Shipping is calculated in checkout
Shipping is calculated in checkout
This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
1584121-99-2
Purity:
≥98%
Formulation:
A crystalline solid
Molecular Formula:
C17H14N2O4S
Molecular Weight:
342.4
Alternative Names:
5-[(2,4-di
Product Description:
An inhibitor of the NF-κB subunit c-Rel; inhibits NF-κB DNA binding (IC50 = 0.1 µM); reduces TNF-α-induced NF-κB activity (IC50 = 4 µM); decreases proliferation of ABC and GCB DLBCLL cells at 3 µM; increases HO-1 expression and ROS production in mitochondria of DLBCL cells but not normal leukocytes; increases survival in a mouse model of GVHD at 24 mg/kg every other day beginning eight days after HSCT; reduces tumor growth in mouse xenograft models of EBV-induced B cell lymphoma, CLL, and Richter syndrome
