Theobromine
Shipping is calculated in checkout
83-67-0
≥98%
A crystalline solid
180.2
3,7-dihydro-3,7-dimethyl-1h-purine-2,6-dione, diurobromine, nsc 5039, sc-15090
- Data sheet: View or download
- MSDS: View or download
A methylxanthine alkaloid with diverse biological activities; derivative of caffeine; adenosine A1 receptor antagonist (IC50s = 200-280 µM in radioligand binding assays using rat brain membranes); increases AMPK phosphorylation and inhibits adipocyte differentiation, ERK and JNK phosphorylation, and IL-6 and TNF-α production in 3T3-L1 preadipocytes cultured in differentiation medium at 150 µg/ml; inhibits decreases in renal cortex SIRT1 activity and increases in NADPH oxidase-dependent ROS production, as well as reduces kidney hypertrophy and albuminuria in a spontaneously hypertensive rat model of streptozotocin-induced diabetes at 5 mg/kg per day; toxic to dogs (LD50 = 250-500 mg/kg)
-20°C
