PKF118-310
Catalogue number:
CAY22440-1 mg
Supplier:
Size:
1 mg
Product is available in:
£42.00
Estimated delivery Wed 7 Aug
Shipping is calculated in checkout
Shipping is calculated in checkout
This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
84-82-2
Purity:
≥98%
Formulation:
A crystalline solid
Molecular Weight:
193.2
Alternative Names:
1,6-dimethyl-pyrimido[5,4-e]-1,2,4-triazine-5,7(1h,6h)-dione, nsc 67078, toxoflavin
- Data sheet: View or download
- MSDS: View or download
Product Description:
An inhibitor of the Tcf4-β-catenin protein interaction; disrupts binding of β-catenin to a GST-Tcf4 fusion protein in HCT116 cell lysates (IC50 = 0.8 µM); blocks appearance of the Tcf4 and β-catenin complex bound to DNA in an EMSA assay; reduces levels of the β-catenin regulated proteins c-Myc and cyclin D1 in HCT116 cells; reduces growth of HCT116, HT-29, PC3, and DU145 cancer cells in vitro (IC50s = 170-300 nM); reduces tumor growth and expression of c-Myc, cyclin D1, and Survivin in a HepG2 mouse xenograft model (1 mg/kg twice per week)
Storage Temperature:
-20°C
