SSR 128129E
Catalogue number:
CAY22128-5 mg
Supplier:
Size:
5 mg
Product is available in:
£142.00
Estimated delivery Wed 7 Aug
Shipping is calculated in checkout
Shipping is calculated in checkout
This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
848318-25-2
Purity:
≥98%
Formulation:
A crystalline solid
Molecular Weight:
346.3
Alternative Names:
2-amino-5-[(1-methoxy-2-methyl-3-indolizinyl)carbonyl]-benzoic acid, monosodium salt
- Data sheet: View or download
- MSDS: View or download
Product Description:
An FGFR inhibitor (IC50 = 1.9 nM); reduces FGF2-induced endothelial cell proliferation and migration (IC50s = 31 and 15.2 nM, respectively); reduces proliferation of cells expressing FGFR1-4 at 100 nM; reduces disease severity and enhances physical performance in a mouse model of arthritis at 30 mg/kg per day; reduces tumor growth and metastasis in a Panc02 mouse orthotopic tumor model; reduces atherosclerotic lesion size in the aortic sinus of apoE-/- mice at 50 mg/kg per day; reduces intimal hyperplasia following jugular vein-to-artery bypass grafting surgery in rats
Storage Temperature:
-20°C
