Ponesimod
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854107-55-4
≥98%
A crystalline solid
461
(2z)-5z-[[3-chloro-4-[(2r)-2,3-dihydroxypropoxy]phenyl]methylene]-3-(2-methylphenyl)-2-(propylimino)-4-thiazolidinone
- Data sheet: View or download
- MSDS: View or download
A potent S1P1 receptor agonist (IC50s = 6, >10,000, 2,068, 1,956, and 142 nM for S1P1-S1P5, respectively, in a radioligand binding assay); selectively activates S1P1 in a GTPγS assay (EC50s = 5.7, >10,000, 105, 1,108, 59.1 nM, for S1P1-S1P5, respectively); reduces the number of circulating lymphocytes in rats in a dose-dependent manner; reduces edema, protein extravasation, neutrophil activity, and skin levels of the proinflammatory cytokines IL-1β, IL-6, IFN-γ, and TNF-α in a mouse model of delayed-type hypersensitivity; prevents footpad swelling in a rat model of adjuvant-induced arthritis
-20°C
