CC-930
Catalogue number:
CAY22466-1 mg
Supplier:
Size:
1 mg
Product is available in:
£47.00
Estimated delivery Wed 7 Aug
Shipping is calculated in checkout
Shipping is calculated in checkout
This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
899805-25-5
Purity:
≥98%
Formulation:
A crystalline solid
Molecular Weight:
448.4
Alternative Names:
trans-4-[[9-[(3s)-tetrahydro-3-furanyl]-8-[(2,4,6-trifluorophenyl)amino]-9h-purin-2-yl]amino]-cyclohexanol, tanzisertib
- Data sheet: View or download
- MSDS: View or download
Product Description:
A potent JNK inhibitor (IC50s = 61, 7, and 6 nM for JNK1, JNK2, and JNK3, respectively); selective for MAP kinases; selective for JNKs over other MAPK family proteins (IC50s = 3,400 and 480 nM for p38α and ERK1, respectively); inhibits JNK in a cell lysate assay (IC50 = 200 nM); blocks phosphorylation of c-Jun in LPS-stimulated human PBMCs; inhibits TNF-α production induced by LPS when administered to rats at doses of 10 and 30 mg/kg; reduces lung fibrosis in a mouse pulmonary fibrosis model
Storage Temperature:
-20°C
