SNX-2112
Catalogue number:
CAY22359-5 mg
Supplier:
Size:
5 mg
Product is available in:
£348.00
Estimated delivery Wed 7 Aug
Shipping is calculated in checkout
Shipping is calculated in checkout
This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
908112-43-6
Purity:
≥98%
Formulation:
A crystalline solid
Molecular Weight:
464.5
Alternative Names:
2-[(trans-4-hydroxycyclohexyl)amino]-4-[4,5,6,7-tetrahydro-6,6-dimethyl-4-oxo-3-(trifluoromethyl)-1h-indazol-1-yl]-benzamide, pf-04928473
- Data sheet: View or download
- MSDS: View or download
Product Description:
A potent Hsp90 inhibitor (Kd = 30 nM); induces down-regulation of client proteins HER2 and Akt in vitro; inhibits proliferation in a panel of cancer cell lines (IC50s = 10-50 nM); inhibits tumor growth in a BT474 breast cancer mouse xenograft model; active metabolite of the prodrug SNX-5542 and preferentially accumulates in tumor tissue of mice treated with a single oral dose of 75 mg/kg SNX-5542
Storage Temperature:
-20°C
