NSC 185058
Catalogue number:
CAY23957-1 mg
Supplier:
Size:
1 mg
Product is available in:
£73.00
Estimated delivery Wed 24 Dec
Shipping is calculated in checkout
Shipping is calculated in checkout
This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
39122-38-8
Purity:
≥98%
Formulation:
A crystalline solid
Molecular Formula:
C11H9N3S
Molecular Weight:
215.3
Alternative Names:
n-2-pyridinyl
Product Description:
An inhibitor of ATG4B; inhibits ATG4B cleavage of LC3B-GST (IC50 = 51 µM) and reduces LC3B lipidation induced by starvation in Saos-2 cells; reduces starvation-induced autophagy and prevents autophagic vacuole formation in Saos-2 and MDA-MB-468 cells (100 µM); decreases autophagy in vivo in mouse liver, inhibits tumor growth in mouse xenograft model, and decreases the number of autophagic vacuoles in osteosarcoma tumors (100 mg/kg)
