Cariprazine (hydrochloride)
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1083076-69-0
≥98%
A crystalline solid
463.9
n'-[trans-4-[2-[4-(2,3-dichlorophenyl)-1-piperazinyl]ethyl]cyclohexyl]-n,n-dimethyl-urea, monohydrochloride, rgh-188
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- MSDS: View or download
An atypical antipsychotic; binds to dopamine D2L, D2S, and D3, 5-HT1A, 5-HT2A, 5-HT2B, histamine H1, and σ1 receptors (Kis = 0.085-23.44 nM); an antagonist of dopamine D2 and D3 receptors (Kbs = 0.759 and 0.316 nM, respectively); a partial agonist at dopamine D2 and D3 receptors; stimulates inositol phosphate production in murine A9 cells expressing human D2L receptors (EC50 = 3.16 nM); inhibits forskolin-induced cAMP accumulation in CHO cells expressing human D3 receptors (EC50 = 2.63 nM); inhibits amphetamine-induced hyperactivity and the conditioned avoidance response in rats (ED50s = 0.12 and 0.84 mg/kg, respectively); inhibits scopolamine-induced learning deficits in a water labyrinth learning test in rats from 0.02-0.08 mg/kg
-20°C
