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133454-47-4
≥98%
A crystalline solid
426.5
1-[4-[3-[4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]propoxy]-3-methoxyphenyl]-ethanone
- Data sheet: View or download
- MSDS: View or download
An atypical antipsychotic and adrenergic, dopamine, and serotonin receptor antagonist; binds to α1-AR, α2-AR, and D2 receptors (Kis = 0.31, 3, and 3.3 nM, respectively) as well as 5-HT1A, 5-HT1D, 5-HT2A, and 5-HT2C receptors (Kis = 33, 15, 0.2, and 14 nM, respectively) in human post-mortem brain tissue; binds to human D1, D3, D4, D5, and rat 5-HT2 receptors (Kis = 216, 7.1, 25, 319, and 3.1 nM, respectively); prevents the reduction in prepulse inhibition induced by apomorphine, PCP, and cirazoline in rats at 1-3 mg/kg; increases the time rats spend in the open arms of an elevated plus maze and the number of social interactions at 0.5 mg/kg, i.p.
-20°C
