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Spi-6, Mouse, pAb

Catalogue number:
HP8035-20UG
Supplier:
Size:
20 µg _$$_
Product is available in:
  • UK
  • Ireland
  • Europe
  • USA
  • Rest of World
£132.00 Shipping is calculated in checkout
Applications:

Flow cytometry, Immuno assays, Western blot

Immunogen:

Recombinant GST-Spi-6

Product Description:

The polyclonal antibody recognizes mouse Spi-6, also known as serpin B9, a cytoplasmic serine protease inhibitor of ~42 kD. Spi-6 is expressed in dendritic cells, lymphocytes and specific cell types at immune-privileged sites. It inactivates granzyme B, a natural occurring inducer of programmed cell death. As such, Spi-6 functions as anti-apoptotic protein. In cytotxic T cells (CTL), Spi-6 is required to protect clonal bursts (expansion) from granzyme B induced cell death. However, it is not required for the development of memory cells. Expression of SPI-6 is of crucial importance in the escape of several tumors from a CTL response and is, therefore, a parameter that influences the feasibility of CTL-mediated immunotherapy of cancer. The polyclonal antibody shows no crossreactivity with mouse proteins related to Spi-6.

HP8035-20UG Spi-6, Mouse, pAb
HP8035-20UG Spi-6, Mouse, pAb
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