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31271-07-5
≥98%
A crystalline solid
396.4
1,3,6,7-tetrahydroxy-2,8-bis(3-methyl-2-buten-1-yl)-9h-xanthen-9-one
- Data sheet: View or download
- MSDS: View or download
A xanthone with diverse biological activities: scavenges DPPH radicals in vitro (IC50 = 23.6 µM); is cytotoxic to HL-60, SMMC-7721, A549, MCF-7, SW480, and BEAS-2B cells in vitro (IC50s = 7.39, 6.57, 10.07, 5.33, 8.4, and 7.43 µM, respectively); inhibits LPS-induced expression of IL-6, IL-10, and TNF-α in human macrophages; macrophage-conditioned media from macrophages pre-incubated with γ-mangostin (30 µM) prior to stimulation with LPS has a reduced ability to induce inflammation and insulin resistance in primary human adipocytes; inhibits carbon tetrachloride-induced increases in serum levels of AST and ALT and decreases in hepatic SOD2 activity and GSH content in a mouse model of liver fibrosis
-20°C
