Sorafenib N-oxide
Catalogue number:
CAY27830-5 mg
Supplier:
Size:
5 mg _$$_
Product is available in:
£509.00
Estimated delivery Fri 2 Aug
Shipping is calculated in checkout
Shipping is calculated in checkout
This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
583840-03-3
Purity:
≥98%
Formulation:
A solid
Molecular Weight:
480.8
Alternative Names:
4-[4-[[[[4-chloro-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]phenoxy]-n-methyl-2-pyridinecarboxamide, 1-oxide, bay 67-3472
- Data sheet: View or download
- MSDS: View or download
Product Description:
An active metabolite of sorafenib; inhibits FLT3-ITD (Kd = 70 nM); inhibits proliferation of MV4-11 AML cells expressing FLT3-ITD (IC50 = 25.8 nM); selective for AML cell lines containing FLT3-ITD over lines containing wild-type FLT3 (IC50s = 3.9-13.3 µM); a linear-mixed inhibitor of CYP3A4 (Ki = 15 µM)
Storage Temperature:
-20°C
