£42.00
Estimated delivery Fri 2 Aug
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This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
33985-68-1
Purity:
≥98%
Formulation:
A solid
Molecular Weight:
352.4
Alternative Names:
3,3'-[(4-methoxyphenyl)methylene]bis-1h-indole, dim-c-pphoch3
- Data sheet: View or download
- MSDS: View or download
Product Description:
A Nur77 receptor agonist; selectively activates Nur77 over PPARγ in reporter assays at 20 µM; inhibits growth of and induces apoptosis in L3.6pL pancreatic cancer cells at 10, 15, and 20 µM; stabilizes nuclear localization of Nur77 and Nurr1 and reduces secretion of pro-inflammatory cytokines in primary mouse astrocytes; oral administration prevents loss of dopaminergic neurons in the substantia nigra pars compacta and striatal dopamine terminals in a mouse model of MPTP-induced Parkinson's disease at 50 mg/kg
Storage Temperature:
-20°C
