Ritlecitinib
Catalogue number:
HY-100754-25mg
Supplier:
Size:
25 mg
Product is available in:
This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
1792180-81-4
Purity:
99.80
Molecular Formula:
C15H19N5O
Molecular Weight:
285.351
Mass Spectrometry:
Reference Materials
Alternative Names:
PF-06651600
- Data sheet: View or download
- MSDS: View or download
- Protocol: View or download
Product Description:
Ritlecitinib (PF-06651600) is a highly selective, orally active, irreversible covalent JAK3 inhibitor (IC50=33 nM) without inhibitory activity towards JAK1, JAK2, and TYK2 (IC50 >10 ยต M). Ritlecitinib rapidly inactivates the JAK3 kinase, and blocks signaling and downstream STAT phosphorylation mediated by common gamma chain cytokines such as IL-2 and IL-15. Ritlecitinib can inhibit Th1/Th17 cell differentiation and function, and effectively suppress preclinical animal models such as alopecia areata, adjuvant-induced arthritis (AIA), and experimental autoimmune encephalomyelitis (EAE)[1][2][3].
