This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
52128-35-5
Purity:
99.22
Molecular Weight:
369.42
Alternative Names:
CI-898
- Data sheet: View or download
- MSDS: View or download
- Protocol: View or download
Product Description:
Trimetrexate (CI-898) is an antibiotic, also a potent and orally active dihydrofolate reductase (DHFR) inhibitor, reducing the production of DNA and RNA precursors and leading to cell death, with IC50 values of 4.74 nM and 1.35 nM for human DHFR and Toxoplasma gondii DHFR. Trimetrexate can also inhibit the growth of various cancer cells. Trimetrexate can be used for researching Pneumocystis carinii pneumonia (PCP) and cancer[1][2][3][4][5].
Storage Temperature:
-20°C, 3 years; 4°C, 2 years (Powder)
