This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
1338934-59-0
Purity:
99.52
Molecular Weight:
361.35
Alternative Names:
Orin1001
- Data sheet: View or download
- MSDS: View or download
- Protocol: View or download
Product Description:
MKC8866, a salicylaldehyde analog, is a potent, selective IRE1 RNase inhibitor with an IC50 of 0.29 µM in human vitro. MKC8866 strongly inhibits Dithiothreitol-induced X-box-binding protein 1-spliced (XBP1s) expression with an EC50 of 0.52 µM and unstresses RPMI 8226 cells with an IC50 of 0.14 µM[1]. MKC8866 inhibits IRE1 RNase in breast cancer cells leading to the decreased production of pro-tumorigenic factors and it can inhibits prostate cancer (PCa) tumor growth[2].
Storage Temperature:
-20°C, 3 years; 4°C, 2 years (Powder)
