Crizotinib (hydrochloride)
Catalogue number:
HY-50878A-100mg
Supplier:
Size:
100 mg _$$_
Product is available in:
This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
1415560-69-8
Purity:
99.86
Molecular Weight:
486.8
Alternative Names:
PF-02341066 hydrochloride
- Data sheet: View or download
- MSDS: View or download
- Protocol: View or download
Product Description:
Crizotinib hydrochloride (PF-02341066 hydrochloride) is an orally bioavailable, selective, and ATP-competitive dual ALK and c-Met inhibitor with IC50s of 20 and 8 nM, respectively. Crizotinib hydrochloride (PF-02341066 hydrochloride) inhibits tyrosine phosphorylation of NPM-ALK and tyrosine phosphorylation of c-Met with IC50s of 24 and 11 nM in cell-based assays, respectively. It is also a ROS proto-oncogene 1 (ROS1) inhibitor. Crizotinib hydrochloride (PF-02341066 hydrochloride) has effective tumor growth inhibition[1][2][3].
Storage Temperature:
4°C (Powder, sealed storage, away from moisture)
