Feglymycin
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209335-49-9
≥95%
1900.9
(2r)-2-(4-hydroxyphenyl)glycyl-(2r)-2-(3,5-dihydroxyphenyl)glycyl-l-valyl-(2r)-2-(3,5-dihydroxyphenyl)glycyl-(2s)-2-(4-hydroxyphenyl)glycyl-(2r)-2-(3,5-dihydroxyphenyl)glycyl-(2s)-2-(4-hydroxyphenyl)glycyl-(2r)-2-(3,5-dihydroxyphenyl)glycyl-l-valyl-(2r)-2
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- MSDS: View or download
A peptide with antibacterial and antiviral activities; active against Gram-positive bacteria (MICs = 32-64 µg/ml); inhibits HIV viral replication in H9 cells (IC50 = ~5 µM); active against clinical isolates of HIV-1 from clades A-D, A/E, and G (EC50s = 0.5-6.7 µM); inhibits HIV-1 NL4.3 binding to human soluble CD4 (EC50 = 4.4 µM) and to CD4+ SupT1 T cells by 74.5% at 10.5 µM; inhibits the E. coli peptidoglycan biosynthesis enzymes MurA and MurC (Kis = 3.4 and 0.3 µM, respectively)
-20°C
