Δ12-Prostaglandin D2

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PGD2 is one of the five primary enzymatic prostaglandins derived directly from PGH2. PGD2 is produced abundantly in the CSF by the lipocalin-type PGD synthase, and in the periphery by myeloid cells including mast cells and basophils by a second, hematopoietic-type PGD synthase. PGD2 is chemically unstable, and its use and analysis is complicated by its short in vivo half-life. .DELTA.12-PGD2 is one of the initial chemical decomposition products of PGD2. .DELTA.12-PGD2 is an intermediate in the pathway leading to .DELTA.12-PGJ2, which is a cyclopentenone prostaglandin with antimitotic and carcinogenic activities.{870,334} The metabolism of .DELTA.12-PGD2 involves addition of thiol nucleophiles, as is the case with the majority of cyclopentenone prostaglandins.{7193}