15(R)-15-methyl Prostaglandin D2
Shipping is calculated in checkout
210978-26-0
≥95%
A solution in methyl acetate
366.5
9α,15r-dihydroxy-11-oxo-15-methyl-prosta-5z,13e-dien-1-oic acid, 15(r)-15-methyl pgd2
- Data sheet: View or download
- MSDS: View or download
The physiological actions of PGD2 include regulation of sleep, lowering of body temperature, inhibition of platelet aggregation and relaxation of vascular smooth muscle.{328,1185,580} PGD2 mediates its effects by 2 distinct G-protein-coupled receptors, DP1{3128} and CRTH2/DP2.{10722,9769} 15(R)-15-methyl PGD2 is a potent, selective agonist for the CRTH2/DP2 receptor.{10723} The EC50 values for eosinophil CD11b expression, actin polymerization, and chemotaxis are 1.4, 3.8, and 1.7 nM, respectively, each of which is approximately 3-5 fold lower than those for PGD2. In contrast the EC50 for the DP1-mediated increase in platelet cAMP by 15(R)-15-methyl PGD2 is >10 µM.{10723}
-20°C