GW 4869 (hydrochloride hydrate)
Catalogue number:
CAY13127-10 mg
Supplier:
Size:
10 mg
Product is available in:
£290.00
Estimated delivery Wed 7 Aug
Shipping is calculated in checkout
Shipping is calculated in checkout
This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
6823-69-4
Purity:
≥90%
Formulation:
A crystalline solid
Molecular Weight:
577.5
Alternative Names:
3,3'-(1,4-phenylene)bis[n-[4-(4,5-dihydro-1h-imidazol-2-yl)phenyl]-dihydrochloride-2-propenamide
- Data sheet: View or download
- MSDS: View or download
Product Description:
An inhibitor of neutral sphingomyelinase (IC50 = 1 µM); selective for neutral sphingomyelinase over acid sphingomyelinase at concentrations up to 150 µM as well as B. cereus PC-PLC, human lyso-PAF PLC, and bovine PP2A at 10 µM; inhibits TNF-α-induced sphingomyelin hydrolysis and TNF-α-induced cell death in MCF-7 cells; reduces the inhibitory effects of OxPAPC and KOdiA-PE on LPS-induction of IL-8 in human aortic endothelial cells; reverses hypoxia-induced pulmonary vasoconstriction in rats at 1 mg/kg
Storage Temperature:
-20°C
