£58.00
Estimated delivery Wed 7 Aug
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This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
299953-00-7
Purity:
≥95%
Formulation:
A crystalline solid
Molecular Weight:
220.3
Alternative Names:
2-amino-5-[(4-hydroxyphenyl)methylene]-4(5h)-thiazolone
- Data sheet: View or download
- MSDS: View or download
Product Description:
A MRN complex inhibitor; inhibits DSB-induced H2AX phosphorylation (IC50 = 66 µM in X. laevis cell-free extracts); inhibits the exonuclease activity of Mre11 in a cell-free assay at 100 µM; induces cell cycle arrest at the G2 phase in TOSA4 cells and inhibits homology-dependent repair in HEK293 cells in a concentration-dependent manner; reduces tumor growth in an LA-N-5 mouse xenograft model when encapsulated in nanoparticles at 50 mg/kg
Storage Temperature:
-20°C