PH-002
Catalogue number:
CAY27739-10 mg
Supplier:
Size:
10 mg
Product is available in:
£315.00
Estimated delivery Wed 7 Aug
Shipping is calculated in checkout
Shipping is calculated in checkout
This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
1311174-68-1
Purity:
≥98%
Formulation:
A solid
Molecular Weight:
491.6
Alternative Names:
4-[[4-[[2-(3,4-dihydro-3-methyl-4-oxo-1-phthalazinyl)acetyl]amino]phenyl]methyl]-1-piperazinecarboxylic acid, 1,1-dimethylethyl ester
- Data sheet: View or download
- MSDS: View or download
Product Description:
An inhibitor of ApoE4 domain interactions (IC50 = 116 nM in a FRET reporter assay for amino- and carboxy-terminal domain interactions); restores intracellular trafficking of ApoE4 to the endoplasmic reticulum and Golgi apparatus in Neuro-2a cells expressing EGFP-ApoE4 or EGFP-ApoE4-R61T at 100 nM; restores levels of mitochondrial complex IV subunit 1 in Neuro-2a cells expressing ApoE4 (EC50 = 39 nM) and increases mitochondrial motility in neurons expressing ApoE4 (EC50 = <1 nM)
Storage Temperature:
-20°C
