LX2343
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333745-53-2
≥98%
A solid
474.9
n-1,3-benzodioxol-5-yl-2-[(5-chloro-2-methoxyphenyl)(phenylsulfonyl)amino]-acetamide
- Data sheet: View or download
- MSDS: View or download
An inhibitor of BACE1 and PI3K (IC50s = 11.43 and 15.99 µM, respectively); inhibits STZ-induced accumulation of Aβ40 and Aβ42 in both HEK293-APPSW and CHO-APP cells in a concentration-dependent manner; inhibits STZ-induced increases in JNK and APPThr668 phosphorylation as well as sAPPβ protein levels; reduces levels of Aβ40 and Aβ42, as well as thioflavine S staining, in cortex and hippocampus in the APP/PS1 transgenic mouse model of Alzheimer’s disease at 10 mg/kg/day; reduces cortical levels of p62 protein and PI3K, Akt, and mTOR phosphorylation; decreases path length and escape latency time in the Morris water maze in APP/PS1 mice at 10 mg/kg/day
-20°C
