Olprinone (hydrochloride)
Shipping is calculated in checkout
119615-63-3
≥98%
A crystalline solid
286.7
1,2-dihydro-5-imidazo[1,2-a]pyridin-6-yl-6-methyl-2-oxo-3-pyridinecarbonitrile, monohydrochloride, loprinone
- Data sheet: View or download
- MSDS: View or download
An inhibitor of PDE3 (IC50 = 0.35 µM for human cardiac enzyme); selective for PDE3 over PDE1 and PDE2 (IC50s = 150 and 100 µM, respectively); induces relaxation of precontracted isolated rabbit renal and carotid arterial rings (IC50s = 40 and 103 nM, respectively); reduces infarct size and improves cardiac function in a rat model of myocardial ischemia-reperfusion injury at 0.6 mg/kg twice per day; reduces cortical and striatal damage, as well as reduces injured cerebral tissue nitrotyrosine formation, apoptosis, and levels of iNOS, IL-1β, and ICAM-1 in a rat model of cerebral ischemia-reperfusion injury at 0.2 mg/kg; inhibits neutrophil infiltration into lung and inhibits increases in serum levels of TNF-α and IL-6 in a rat model of LPS-induced lung inflammation at 0.2 mg/kg
-20°C
