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84379-13-5
≥98%
A solid
418.3
8-bromo-11,12,13,13as-tetrahydro-9-oxo-9h-imidazo[1,5-a]pyrrolo[2,1-c][1,4]benzodiazepine-1-carboxylic acid, 1,1-dimethylethyl ester, ro 16-6028
- Data sheet: View or download
- MSDS: View or download
A positive allosteric modulator of GABAA receptors with anticonvulsant and anxiolytic activity; potentiates GABA-gated chloride currents in rat cortical neurons and in HEK293 cells expressing α1β1γ2 subunit-containing GABAA receptors (EC50s = 60 and 10 nM, respectively); inhibits binding of the benzodiazepine diazepam to rat cerebral cortex homogenates (IC50 = 2.2 nM); inhibits PTZ- and MES-induced tonic convulsions in rats (ED50s = 0.07 and 0.48 mg/kg, respectively); increases the number of open arm entries and percentage of time spent in the open arms of the elevated plus maze in mice at 5-30 mg/kg
-20°C
