Astilbin

A flavonoid with diverse biological activities; inhibits cisplatin-induced increases in apoptosis and ROS in HEK293 cells at 200 µM; increases renal GSH levels and SOD and catalase activity and reduces serum creatinine and BUN levels, renal IL-1β, IL-6, and TNF-α levels, apoptosis in kidney tissue, and kidney injury in a mouse model of cisplatin-induced nephrotoxicity at 50 mg/kg; reduces loss of dopaminergic neurons in the substantia nigra and increases striatal GSH levels and SOD activity in a mouse model of MPTP-induced Parkinson's disease at 50 mg/kg per day; reduces motor deficits in a mouse model of Parkinson's disease; reduces cell viability of MDA-MB-231 and MCF-7 cells (IC50s = 167.9 and 191.6 µM, respectively), as well as inhibits migration and increases apoptosis at 50 and 200 µM; reduces tumor growth in an MCF-7 mouse xenograft model at 20 mg/kg every other day for 14 days