Iloprost

An IP and EP1 receptor agonist; selectively binds to IP and EP1 receptors (Ki = 11 nM for both) over EP2, EP4, DP, FP, and TP receptors (Kis = 1,870, 284, 1,035, 619, and 6,487 nM, respectively) but also binds to the EP3 receptor (Ki = 56 nM); increases cAMP levels in HEK293 cells expressing IP or EP3 receptors (EC50s = 0.37 and 27.5 nM, respectively); increases calcium levels in HEK293 cells expressing the EP1 receptor (EC50 = 0.3 nM); inhibits ADP-, thrombin-, and collagen-induced platelet aggregation in isolated human platelet-rich plasma (IC50s = 1.07, 0.71, and 0.24 nM, respectively); increases the time to occlusive coronary artery thrombosis in a porcine model of electrically induced coronary artery thrombosis at 100 ng/kg per minute; reduces right ventricular systolic pressure and reverses vascular remodeling in rats in a model of monocrotaline-induced chronic pulmonary hypertension at 130-1,300 ng/kg per minute