This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
95975-55-6
Purity:
99.95
Molecular Weight:
312.45
Alternative Names:
Z/E-Guggulsterone
- Data sheet: View or download
- MSDS: View or download
- Protocol: View or download
Product Description:
Guggulsterone is a plant sterol derived from the gum resin of the tree Commiphora wightii. Guggulsterone inhibits the growth of a wide variety of tumor cells and induces apoptosis through down regulation of antiapoptotic gene products (IAP1, xIAP, Bfl-1/A1, Bcl-2, cFLIP and survivin), modulation of cell cycle proteins (cyclin D1 and c-Myc), activation of caspases and JNK, inhibition of Akt[1]. Guggulsterone, a farnesoid X receptor (FXR) antagonist, decreases CDCA-induced FXR activation with IC50s of 17 and 15 µM for Z- and E-Guggulsterone, respectively[2].
Storage Temperature:
4°C (Powder, protect from light)
