This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
923604-59-5
Purity:
99.9
Molecular Weight:
749.94
Alternative Names:
TMC435; TMC435350
- Data sheet: View or download
- MSDS: View or download
- Protocol: View or download
Product Description:
Simeprevir (TMC435; TMC435350) is an oral, potent and highly specific hepatitis C virus (HCV) NS3/4A protease inhibitor with a Ki of 0.36 nM. Simeprevir inhibits HCV replication with an EC50 of 7.8 nM. Simeprevir also potently suppresses SARS-CoV-2 replication and synergizes with Remdesivir. Simeprevir inhibits the main protease (Mpro) and the RNA-dependent RNA polymerase (RdRp) of SARS-CoV-2, and also modulates host immune responses[1][4].
Storage Temperature:
-20°C, 3 years; 4°C, 2 years (Powder)
