AMG-548 (dihydrochloride)
Catalogue number:
HY-108642B-1mL
Supplier:
Size:
1 ml _$$_
Product is available in:
This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
2518299-32-4
Purity:
99.85
Molecular Formula:
C29H29Cl2N5O
Molecular Weight:
534.48
- Data sheet: View or download
- MSDS: View or download
- Protocol: View or download
Product Description:
AMG-548 dihydrochloride, an orally active and selective p38α inhibitor (Ki=0.5 nM), shows slightly selective over p38β (Ki=36 nM) and >1000 fold selective against p38γ and p38δ. AMG-548 dihydrochloride is also extremely potent in the inhibition of whole blood LPS stimulated TNFα (IC50=3 nM)[1]. AMG-548 dihydrochloride inhibits Wnt signaling by directly inhibiting Casein kinase 1 isoforms δ and ε[2].
Storage Temperature:
-20°C (Powder, sealed storage, away from moisture)
