This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
171714-84-4
Purity:
98.67
Molecular Formula:
C22H22N2O6
Molecular Weight:
410.42
Alternative Names:
Lu-135252
- Data sheet: View or download
- MSDS: View or download
- Protocol: View or download
Product Description:
Darusentan (Lu-135252) is a selective endothelin receptor A (ET-A) receptor antagonist, which binds with a Ki of 1.4 nM to the ET-A receptor and a Ki of 184 nM to ET-B receptor, respectively with a 100-fold selectivity for ETA rather than ETB receptors[1]. Darusentan competes for radiolabeled endothelin binding in rat aortic vascular smooth muscle cells (RAVSMs) membranes with single-site kinetics, exhibiting a Ki of 13 nM[2].
Storage Temperature:
-20°C, 3 years; 4°C, 2 years (Powder)
