Raphin1 (acetate)
Catalogue number:
HY-123960A-50mg
Supplier:
Size:
50 mg _$$_
Product is available in:
This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
2242616-04-0
Purity:
99.88
Molecular Formula:
C10H12Cl2N4O2
Molecular Weight:
291.13
- Data sheet: View or download
- MSDS: View or download
- Protocol: View or download
Product Description:
Raphin1 acetate is an orally bioavailable, selective inhibitor of the regulatory phosphatase PPP1R15B (R15B). Raphin1 acetate binds strongly to the R15B-PP1c holophosphatase (Kd=33 nM), and shows ~30-fold selective in binding R15B-PP1c over R15A-PP1c. Raphin1 acetate crosses the blood-brain barrier, and reduces organismal and molecular deficits in a mouse model of a protein misfolding disease[1].
Storage Temperature:
4°C (Powder, sealed storage, away from moisture)
