This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
1357349-91-7
Purity:
99.62
Molecular Formula:
C16H15N5
Molecular Weight:
277.32
- Data sheet: View or download
- MSDS: View or download
- Protocol: View or download
Product Description:
SPP-86 is a potent and selective cell permeable inhibitor of RET tyrosine kinase, with an IC50 of 8 nM. SPP-86 inhibits RET-induced phosphatidylinositide 3-kinases (PI3K)/Akt and MAPK signaling, also inhibits RET-induced estrogen receptorα (ERα) phosphorylation in MCF7 cells[1]. SPP-86 is a click chemistry reagent, itcontains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
Storage Temperature:
-20°C, 3 years; 4°C, 2 years (Powder)
