IL-6, Mouse, mAb MP5-20F3

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The antibody neutralizes mouse interleukin 6 (IL-6). It does not cross-react with LPS (the component of thebacterial cell wall which is considered responsible for the toxicity of gram-negative bacteria) and TNFalphanor does it bind to either human or rat IL-6. The antibody inhibits IL-6 induced proliferation of the B9assay. IL-6 is a pluripotent 20-22 kDa cytokine which plays a role in the pathophysiology of severeinfection and regulates the immune response, acute phase reaction and haematopoiesis. IL-6 plays acritical role in B-cell differentiation to plasma cells and is a potent growth factor for plasmacytoma andmyeloma. Continuous IL-6 gene expression makes an essential contribution to a multistep oncogenesis ofplasma cell neoplasia. IL-6 is a very useful culture supplement for the generation of a high number ofantibody-producing hybridomas.