£56.00
Estimated delivery Wed 24 Dec
Shipping is calculated in checkout
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This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
1429639-50-8
Purity:
≥98%
Formulation:
A crystalline solid
Molecular Formula:
C22H29N5O4S
Molecular Weight:
459.56296
Alternative Names:
n-[4-[5,7-
Product Description:
An mTOR inhibitor (Kd = 6.3 nM); 1,000-fold selective for mTOR over a panel of 285 kinases; inhibits phosphorylation of S6RP and Akt in HEK293T cells (IC50s = 14.5 and 14.8 nM, respectively); inhibits IFN-γ secretion in IL-2, anti-CD3, and anti-CD28 antibody-stimulated human whole blood (IC50 = 226 nM); reduces fore paw joint erythema and swelling in a mouse model of collagen-induced arthritis at 10 mg/kg; inhibits intratumor mTOR activity and reduces tumor growth in an OCC-1 oral cavity carcinoma mouse xenograft model at 20 mg/kg
