Miltefosine
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58066-85-6
≥98%
A crystalline solid
407.6
2-[[(hexadecyloxy)hydroxyphosphinyl]oxy]-n,n,n-trimethyl-ethanaminium, inner salt, hexadecylphosphocholine, hpc, nsc 605583
- Data sheet: View or download
- MSDS: View or download
An inhibitor of CCT; inhibits liposome-induced CCT activity in MDCK cell homogenates from 10-50 µM, as well as induces translocation of CCT from the cell membrane to the cytosol in MDCK cells; inhibits PMA-induced phosphatidylcholine biosynthesis in MDCK and HeLa cells at 50 µM; inhibits phosphatidylserine-activated PKC (IC50 = 62 µM), as well as PMA-induced morphological changes and proliferation of MDCK cells; active against clinical isolate promastigotes of L. infantum (EC50s = 5-25 µM); topical application completely eradicates L. amazonensis and induces re-epithelialization of lesions in a mouse model of cutaneous leishmaniasis at 0.5%
-20°C
