This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
403604-85-3
Purity:
99.67
Molecular Formula:
C24H21N5O5S
Molecular Weight:
491.52
Alternative Names:
YM598 (free base)
- Data sheet: View or download
- MSDS: View or download
- Protocol: View or download
Product Description:
Nebentan (YM598 free base) is a potent, selective and orally active non-peptide endothelin ETA receptor antagonist through the modification of Bosentan (HY-A0013). Nebentan inhibits [125I] endothelin-1 binding to cloned human endothelin ETA and ETB receptor, with Ki of 0.697 nM and 569 nM, respectively[1]. YM598 can ameliorate the progression of cor pulmonale and myocardial infarction in vivo[2].
Storage Temperature:
-20°C, 3 years; 4°C, 2 years (Powder)