This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
2748220-93-9
Purity:
99.44
Molecular Formula:
C30H34F3N7O5
Molecular Weight:
629.63
- Data sheet: View or download
- MSDS: View or download
- Protocol: View or download
Product Description:
YKL-5-124 TFA is a potent, selective, irreversible and covalent CDK7 inhibitor with IC50s of 53.5 nM and 9.7 nM for CDK7 and CDK7/Mat1/CycH, respectively. YKL-5-124 TFA is >100-fold greater selective for CDK7 than CDK9 and CDK2, and inactive against CDK12 and CDK13. YKL-5-124 TFA induces a strong cell-cycle arrest, inhibits E2F-driven gene expression, and exhibits little effect on RNA polymerase II phosphorylation status[1].
Storage Temperature:
4°C (Powder, sealed storage, away from moisture)