This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
2285330-15-4
Purity:
98
Molecular Formula:
C17H20BNO5
Molecular Weight:
329.16
- Data sheet: View or download
- MSDS: View or download
- Protocol: View or download
Product Description:
M3258 is an orally bioavailable, potent, reversible and highly selective immunoproteasome subunit LMP7 (β5i) inhibitor. M3258 exerts high biochemical (IC50=3.6 nM) and cellular (IC50=3.4 nM) potency against the LMP7 subunit. M3258 shows strong antitumor efficacy in multiple myeloma xenograft models. M3258 leads to a significant and prolonged suppression of tumor LMP7 activity and ubiquitinated protein turnover and the induction of apoptosis in multiple myeloma cells[1][2].
Storage Temperature:
-20°C, 3 years; 4°C, 2 years (Powder)