PRX-08066
Catalogue number:
CAY31477-10 mg
Supplier:
Size:
10 mg
Product is available in:
£559.00
Estimated delivery Wed 7 Aug
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This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
866206-54-4
Purity:
≥95%
Formulation:
A crystalline solid
Molecular Weight:
401.9
Alternative Names:
5-[[4-[(6-chlorothieno[2,3-d]pyrimidin-4-yl)amino]-1-piperidinyl]methyl]-2-fluoro-benzonitrile
- Data sheet: View or download
- MSDS: View or download
Product Description:
A 5-HT2B receptor antagonist; binds to 5-HT2B receptors (Ki = 3.4 nM); inhibits 5-HT-induced MAPK activation and thymidine incorporation in CHO cells expressing human 5-HT2B (IC50s = ~12 and ~3 nM, respectively); reduces peak pulmonary arterial pressure and right ventricular hypertrophy in a rat model of MCT-induced pulmonary hypertension at 50 and 100 mg/kg
Storage Temperature:
-20°C